Anesthesia

Hypothyroidism

Hypothyroidism

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Clinical causes
Clinical manifestations
Diagnosis
Treatment
Preoperative management
Intraoperative management
Postoperative management

Clinical causes:
-Hashimotos thyroiditis
-iodine deficiency
-radioactive iodine
-antithyroid medications
-thyroidectomy
-secondary hypothyroidism

Clinical manifestations
-weight gain
-cold intolerance
-muscle fatigue
-lethargy
-constipation
-reflex decreased (hyporeflexia)
-depression

Diagnosis:

Primary hypothyroidism:
-decreased T3
-decreased T4
-increased TSH

Secondary hypothyroidism:
-decreased T3
-decreased T4
-decreased TSH

Treatment:

Oral replacement:
-physiological effect within few days
-clinical improvement within several weeks

Myxedema/emergency:
-loading dose: levothyroxine 300 - 500mg
-maintenence doses: ex. levothyroxine 50 mg q day

Preoperative management:

Elective surgery:
-thyroid hormone level should be therapeutic

Emergency surgery:
give thyroid hormone prior to procedure in patients with:
-uncorrected severe hypothyroidism T4< 1mg/dL
-myxedema coma

Premedication:
-may not be required due to the sedative nature of the disease (lethargy, depression)
-may be more prone to opiod induced respiratory depression

Intraoperative management:
induction: ketamine may be considered induction agent of choice
Airway: may be difficult intubation due to large tongue

CNS:
same MAC requirements

CVS:
senstive to cardiodepressant effects of volatile anesthetics due to:
-decreased intravascular volume therefore decreased preload
-blunted baroreceptor response theferefore decreased HR
-overall decreased cardiac output

Other possible intraoperative complications:
-hypoglycemia
-hyponatremia
-hypothermia
-large tongue for difficult ventilation/intubation

Postoperative management

May have delayed emergence/recovery from GA due to:
-hypothermia
-respiratory depression
-delayed/slowed drug biotransformation
*therefore may require prolonged mechanical ventilation
*ketorolac may be preferred to opiod analgesia due to less risk of drug induced respiratory depression

Comments

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apneic oxygenation
-100% oxygen insufflated at a rate greater than the oxygen consumption while ventilation has been discontinued -limited use of this technique SK0-002 exam to about 10 – 20 minutes due to progressive increase in PaC02 -↑PaC02 6 mmHg for the 1st minute then ↑PaC02 3 mmHg every minute thereafter
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early extubation 70-553 exam help decrease the risk of:-pulmonary barotraumas -pulmonary infection patients with decreased or marginal pulmonary reserve: -often are left intubated until 640-801 exam weaning parameters and extubation criteria are met -if left intubated , single lumen tube should be placed instead of the already placed double lumen tube